HCID 71269820, 화합물 → (3aR,6aR)-5-Methyloctahydropyrrolo[3,4-b]pyrrole

HRID 1842700

반응식

HRID 1842700 반응식
[CH3:1][N:2]1[CH2:6][C@@H:5]2[N:7]([C@@H](C3C=CC=CC=3)C)[CH2:8][CH2:9][C@@H:4]2[CH2:3]1>[Pd].C(O)C>[CH3:1][N:2]1[CH2:3][C@@H:4]2[C@@H:5]([NH:7][CH2:8][CH2:9]2)[CH2:6]1

참가 물질

4

반응물 1

HCID 71269820HCID 71269820, 화합물2회

생성물 1

HCID 44221716(3aR,6aR)-5-Methyloctahydropyrrolo[3,4-b]pyrrole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Palladium on carbon (10 g) was added to a solution of (3aR,6aR)-5-methyl-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[3,2-c]pyrrole (Intermediate 38, 20 g, 0.087 mol) in ethanol (500 mL) under N2. The resulting mixture was hydrogenated at 70° C./45 psi for 24 h. The mixture was then filtered and the filtrate was concentrated in vacuo to give the title compound as a (10.9 g, 99%) solid; 1H NMR: 1.59-1.66 (1H, m), 1.86-1.95 (1H, m), 2.18 (s, 3H), 2.28-2.34 (2H, m), 2.46-2.47 (1H, m), 2.73 (2H, d), 3.00 (2H, m), 3.90 (2H, m).

후처리

  1. customwas hydrogenated at 70° C.
  2. customfor 24 h
  3. filtrationThe mixture was then filtered
  4. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-90a894b7b86b43eab1a61d2cd4468c75
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946235B2

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