Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1842733생성일: 2026년 10월 27일
p-Toluenesulfonic acid monohydrate → 5-chloro-N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine
https://huagongshe.com/reaction/1842733
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 반응물 | 3-(2,5-Dichloropyrimidin-4-yl)-1H-indole | HCID 56655376 | — |
| 반응물 | 4-Fluoro-2-methoxy-5-nitroaniline | HCID 57429072 | — |
| 용매 | 2-Pentanol | HCID 22386 | — |
| 생성물 | 5-chloro-N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1H-indol-3-yl)pyrimidin-2-amine | HCID 71240894 | — |
반응 단계
A mixture of 3-(2,5-dichloropyrimidin-4-yl)-1H-indole (Intermediate 11, 391 mg, 1.48 mmol), 4-fluoro-2-methoxy-5-nitroaniline (Intermediate 23, 289 mg, 1.55 mmol) and p-toluenesulfonic acid monohydrate (310 mg, 1.63 mmol) in 2-pentanol (25 mL) was heated at 125° C. for 18 h. The mixture was cooled and used in the next step without further purification; m/z: ES+ MH+ 414.12.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08946235B2 |
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| 출처 데이터셋 | uspto-grants-2015_02 |
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| ORD ID | ord-3ece77d72519469a8bc3c96e1c1af865 |
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| 출처 메모 | uspto-grants-2015_02 |
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