p-Toluenesulfonic acid → N-(4-fluoro-2-methoxy-5-nitrophenyl)-5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-amine

참여 물질

역할	이름	HCID	투입량
반응물	p-Toluenesulfonic acid	HCID 6101	—
반응물	4-Fluoro-2-methoxy-5-nitroaniline	HCID 57429072	—
반응물	3-(2-chloro-5-methylpyrimidin-4-yl)-1-methyl-1H-indole	HCID 86677338	—
용매	2-Pentanol	HCID 22386	—
생성물	N-(4-fluoro-2-methoxy-5-nitrophenyl)-5-methyl-4-(1-methylindol-3-yl)pyrimidin-2-amine	HCID 71239199	—

반응 조건

온도	125 °C

반응 단계

A mixture of 3-(2-chloro-5-methylpyrimidin-4-yl)-1-methyl-1H-indole (Intermediate 80, 350 mg, 1.36 mmol), 4-fluoro-2-methoxy-5-nitroaniline (Intermediate 23, 265 mg, 1.43 mmol) and p-toluenesulfonic acid (284 mg, 1.49 mmol) in 2-pentanol (25 mL) was heated at 125° C. for 24 h. The mixture was then cooled and concentrated in vacuo. The resulting gum was used without further purification; m/z: ES+ MH+ 240.13.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08946235B2
출처 데이터셋	uspto-grants-2015_02
ORD ID	ord-c1d648686cb44942b8236cb79171947c
출처 메모	uspto-grants-2015_02