2-(2-Fluoro-4-nitrophenyl)ethan-1-ol → 2-(4-Amino-2-fluorophenyl)ethanol

HRID 1842955노트

반응식

HRID 1842955 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:11][CH2:12][OH:13])=[C:2]([F:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 866721582-(2-Fluoro-4-nitrophenyl)ethan-1-ol

생성물 1

HCID 450906002-(4-Amino-2-fluorophenyl)ethanol수율 89.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a stirred solution of 2-(2-fluoro-4-nitrophenyl)ethanol (200 mg, 0.94 mmol, 1.0 eq) in ethanol (10 mL) was added 10% Pd/C (50 mg) and the mixture was stirred under a H2 gas balloon at RT for 5 h. The reaction mixture was passed through a celite bed and the solvent of the filtrate evaporated to get 2-(4-amino-2-fluorophenyl)ethanol (130 mg, 75%) as a viscous oil (TLC system: EtOAc/PE (1:1), Rf: 0.2).

후처리

  1. customthe solvent of the filtrate evaporated

출처 및 근거

ORD 기록
ord-9b2a5642517d49d6990effef8d5a1be0
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946204B2

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