Methanesulfonyl chloride → N-[(4-bromophenyl)methyl]methanesulfonamide

HRID 1842982노트

반응식

HRID 1842982 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1.[CH3:10][S:11](Cl)(=[O:13])=[O:12]>N1C=CC=CC=1.ClCCl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][S:11]([CH3:10])(=[O:13])=[O:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 31297Methanesulfonyl chlorideHCID 775714-Bromobenzylamine

생성물 1

HCID 19027423N-[(4-bromophenyl)methyl]methanesulfonamide수율 95.1%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of (4-bromophenyl)methanamine (500 mg, 2.687 mmol) in pyridine were added methanesulfonyl chloride (0.4 mL, 5.106 mmol) at 0° C. The reaction mixture was stirred for 1 h, then diluted with dichloromethane. The mixture was washed with water. The organic layer was dried (MgSO4) and filtered. The solvent removed in vacuo. The crude product was purified by CC. N-(4-bromobenzyl)methanesulfonamide (675 mg) was obtained (95% yield).

후처리

  1. washThe mixture was washed with water
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered
  4. customThe solvent removed in vacuo
  5. customThe crude product was purified by CC

출처 및 근거

ORD 기록
ord-35ab45cc85a9468f8169969d6b950cf5
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946204B2

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