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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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1,2-Dichloroethane → N-[[2-(3-Chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-2-[4-[[(ethylsulfonyl)amino]-methyl]-3-fluoro-phenyl]-propionamide

HRID 1842988
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HRID 1842988 반응식
[CH2:1]([S:3]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([CH3:18])[C:15]([OH:17])=O)=[CH:10][C:9]=1[F:19])(=[O:5])=[O:4])[CH3:2].[Cl:20][C:21]1[CH:22]=[C:23]([N:27]2[C:31]([CH2:32][NH2:33])=[CH:30][C:29]([C:34]([F:37])([F:36])[F:35])=[N:28]2)[CH:24]=[CH:25][CH:26]=1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl>O1CCOCC1>[Cl:20][C:21]1[CH:22]=[C:23]([N:27]2[C:31]([CH2:32][NH:33][C:15](=[O:17])[CH:14]([C:11]3[CH:12]=[CH:13][C:8]([CH2:7][NH:6][S:3]([CH2:1][CH3:2])(=[O:4])=[O:5])=[C:9]([F:19])[CH:10]=3)[CH3:18])=[CH:30][C:29]([C:34]([F:35])([F:36])[F:37])=[N:28]2)[CH:24]=[CH:25][CH:26]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

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반응물 4

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 66644230(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamineHCID 708165692-(4-(Ethylsulfonamidomethyl)-3-fluorophenyl)propanoic acid

생성물 1

HCID 70816450N-[[2-(3-Chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]-methyl]-2-[4-[[(ethylsulfonyl)amino]-methyl]-3-fluoro-phenyl]-propionamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2-(4-(ethyl-sulfonamidomethyl)-3-fluorophenyl)propanoic acid (60 mg, 0.207 mmol) and (1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine (63 mg, 0.228 mmol) were dissolved and mixed in 1,4-dioxane followed by addition of HOBt (42 mg, 0.310 mmol) and EDC (60 mg, 0.313 mmol) and TEA (0.07 mL, 0.518 mmol). The reaction mixture was stirred for overnight and then quenched by water and extracted with EtOAc. Drying (MgSO4) and evaporation of the ethyl acetate followed and the residue was purified by CC (EtOAc/n-hexane) to give the example B17 in pure form (104 mg, 92%).

후처리

  1. customquenched by water
  2. extractionextracted with EtOAc
  3. customDrying
  4. custom(MgSO4) and evaporation of the ethyl acetate
  5. customthe residue was purified by CC (EtOAc/n-hexane)
  6. customto give the example

출처 및 근거

ORD 기록
ord-f5165c45d53541fcabadbf8c95729c4f
출처 데이터셋
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08946204B2

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