Oxalyl chloride → 4-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride

HRID 1843056노트

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HRID 1843056 반응식
[F:1][CH:2]([F:19])[C:3]1[C:8]([C:9](O)=[O:10])=[CH:7][N:6]=[C:5]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])[N:4]=1.C(Cl)(=O)C([Cl:23])=O>ClCCl.CN(C)C=O>[F:1][CH:2]([F:19])[C:3]1[C:8]([C:9]([Cl:23])=[O:10])=[CH:7][N:6]=[C:5]([C:12]([F:18])([F:17])[C:13]([F:16])([F:15])[F:14])[N:4]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 866600764-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid

생성물 1

HCID 866600754-(Difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

In 10 ml of dichloromethane, 467 mg of 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carboxylic acid are admixed with two drops of N,N-dimethylformamide and cooled to 0° C. Following the dropwise addition of 167 μl of oxalyl chloride, the reaction mixture is stirred at room temperature for three hours and then concentrated by evaporation. This gives the crude product 4-(difluoromethyl)-2-(pentafluoroethyl)pyrimidine-5-carbonyl chloride.

후처리

  1. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-8dd05b45fa9347e3abbf331a6b713599
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946234B2

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