Triethylamine → Lenalidomide

HRID 1843449노트

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HRID 1843449 반응식
[CH2:1]1[CH:8]([N:9]2[C:13](=[O:14])[C:12]3[CH:15]=[CH:16][CH:17]=[C:18]([NH2:19])[C:11]=3[CH2:10]2)[C:6](=[O:7])[NH:5][C:3](=[O:4])[CH2:2]1.Cl.C(N(CC)CC)C>CO>[NH2:19][C:18]1[CH:17]=[CH:16][CH:15]=[C:12]2[C:11]=1[CH2:10][N:9]([CH:8]1[CH2:1][CH2:2][C:3](=[O:4])[NH:5][C:6]1=[O:7])[C:13]2=[O:14]

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 44234581Lenalidomide hydrochloride

생성물 1

HCID 216326Lenalidomide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
7.5 °C

실험 절차

The filtered lenalidomide hydrochloride was resuspended in methanol (500 ml) and triethylamine (1.1 mole equivalent) was slowly added to the reaction mixture. The reaction mixture was cooled to 5-10° C. and the liberated lenalidomide was filtered, washed with methanol and dried.

후처리

  1. filtrationthe liberated lenalidomide was filtered
  2. washwashed with methanol
  3. customdried

출처 및 근거

ORD 기록
ord-8f89a87239754c5281a06b3274869598
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946265B2

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