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Diethyl Ether → HCID 178508384, 화합물

HRID 1843667
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HRID 1843667 반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:22]3[CH:23]=[C:24]([NH:28][S:29]([C:32]4[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=4[F:39])(=[O:31])=[O:30])[CH:25]=[CH:26][CH:27]=3)=[N:10][N:11](CC3C=CC(OC)=CC=3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.C(OCC)C>FC(F)(F)C(O)=O>[NH2:1][C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:22]3[CH:23]=[C:24]([NH:28][S:29]([C:32]4[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=4[F:39])(=[O:30])=[O:31])[CH:25]=[CH:26][CH:27]=3)=[N:10][NH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=1
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참가 물질

4

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HCID 3283Diethyl EtherHCID 67184347N-{3-[4-(2-aminopyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazol-3-yl]phenyl}-2,5-difluorobenzenesulfonamide

생성물 1

HCID 178508384HCID 178508384, 화합물수율 17%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

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온도
70 °C

실험 절차

80 mg (0.14 mmol) of N-{3-[4-(2-aminopyrimidin-4-yl)-1-(4-methoxybenzyl)-1H-pyrazol-3-yl]phenyl}-2,5-difluorobenzenesulfonamide were dissolved in 5 ml of trifluoroacetic acid and the resulting solution was heated at 70° C. under stirring for 2 hours. The solvent was removed in vacuo and the residue taken up with dichloromethane and washed with aqueous sodium hydrogenocarbonate. The organic phase was then dried over sodium sulphate and evaporated, giving, after trituration with diethylether, 10 mg (17%) of the title compound.

후처리

  1. customThe solvent was removed in vacuo
  2. washwashed with aqueous sodium hydrogenocarbonate
  3. dry with materialThe organic phase was then dried over sodium sulphate
  4. customevaporated
  5. customgiving

출처 및 근거

ORD 기록
ord-ed0c3d2aca7e4d39a21e42f467a2e898
출처 데이터셋
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08946250B2

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