Methyl 3-(2-(tert-butoxy)-2-oxoethoxy)benzoate → [3-(Methoxycarbonyl)phenoxy]acetic acid
반응식
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][C:10]([O:12]C(C)(C)C)=[O:11])=[O:4]>FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1.ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][CH2:9][C:10]([OH:12])=[O:11])=[O:4]참가 물질
5
실험 절차
A solution of t-butyl [3-(methoxycarbonyl)phenoxy]acetate in trifluoroacetic acid (1 kg), anisole (100 mL) and dichloromethane (1 L) was stirred at room temperature for 48 hours. The reaction mixture was concentrated and then the residue was crystallized from diisopropyl ether to obtain the title compound (467 g, 86%) as a white solid.
후처리
- concentrationThe reaction mixture was concentrated
- customthe residue was crystallized from diisopropyl ether
출처 및 근거
- ORD 기록
- ord-b38f9c98b5864a879d1efd653c9006d9
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946264B2
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