Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Diaminocyclohexane, trans- → 2-(4-Methyl-pyridin-3-yl)-3,4-dihydro-2H-benzo[4,5]thieno[3,2-c]pyridin-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Diaminocyclohexane, trans- | HCID 43806 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | 3-Iodo-4-methylpyridine | HCID 14423513 | — |
| 반응물 | 3,4-Dihydro-[1]benzothieno[3,2-c]pyridin-1(2H)-one | HCID 20074905 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-(4-Methyl-pyridin-3-yl)-3,4-dihydro-2H-benzo[4,5]thieno[3,2-c]pyridin-1-one | HCID 56940971 | 43.7% |
반응 단계
Using analogous reaction conditions as described in Example 1, 3,4-dihydro-2H-benzo[4,5]thieno[3,2-c]pyridin-1-one (I-9d: 0.15 g, 0.0007 mol) was reacted with 3-iodo-4-methyl-pyridine (0.178 g, 0.0008 mol), 1,4-dioxane (50 mL), copper iodide (0.014 g, 0.00007 mol), trans-1,2-diamino cyclohexane (0.03 g, 0.0002 mol) and potassium phosphate (0.39 g, 0.0018 mol) to afford the crude product. Purification by column chromatography on silica gel (1.5% methanol in CHCl3) afforded 90 mg of the product (39.13% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08946260B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-a31e4959383d47e7952b8dc741c48f7a |
| 출처 메모 | uspto-grants-2015_02 |