Chlorotrimethylsilane → 2-(4-Bromothiophen-2-yl)ethan-1-amine

HRID 1843859노트

반응식

HRID 1843859 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][N+:9]([O-])=O)[S:5][CH:6]=1.[Li+].[BH4-].Cl[Si](C)(C)C>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:7][CH2:8][NH2:9])[S:5][CH:6]=1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 27323634-bromo-2-(2-nitrovinyl)thiopheneHCID 4148881Lithium borohydride

생성물 1

HCID 150366152-(4-Bromothiophen-2-yl)ethan-1-amine수율 99.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Using analogous reaction conditions and workup as described in Example 14, step 2, 4-bromo-2-(2-nitro-vinyl)-thiophene (5 g, 21.367 mmol) in dry THF (150 mL) was reacted with LiBH4 (1.86 g, 85.470 mmol), chloro trimethyl silane (21.6 mL, 170.576 mmol) to afford 4.4 g of the crude product which was used in the next step without further purification.

후처리

  1. customreaction conditions and workup

출처 및 근거

ORD 기록
ord-b8e417b0f9044c2d84edc9f29bfb0afe
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946260B2

반응 노트

불러오는 중…