1,2-Diaminocyclohexane, trans- → HCID 56942890, 화합물

HRID 1843875

반응식

HRID 1843875 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][NH:9][C:10]2=[O:13])=[CH:5][CH:4]=1.Br[C:17]1[CH:18]=[N:19][CH:20]=[CH:21][C:22]=1[C:23]([F:26])([F:25])[F:24].N[C@@H]1CCCC[C@H]1N.P([O-])([O-])([O-])=O.[K+].[K+].[K+]>[Cu](I)I.O1CCOCC1>[F:15][C:2]([F:1])([F:14])[C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][N:9]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][C:22]=3[C:23]([F:26])([F:25])[F:24])[C:10]2=[O:13])=[CH:5][CH:4]=1

참가 물질

7

반응물 4

HCID 438061,2-Diaminocyclohexane, trans-HCID 62657Potassium Phosphate, TribasicHCID 199372633-Bromo-4-(trifluoromethyl)pyridineHCID 668015937-(Trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one

생성물 1

HCID 56942890HCID 56942890, 화합물수율 6.5%

시약·촉매·용매 2

HCID 83717Copper iodide촉매HCID 312751,4-Dioxane용매

실험 절차

Using analogous reaction conditions as described in Example 1, 7-trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one (I-16c: 150 mg, 0.684 mmol) was reacted with 3-bromo-4-trifluoromethyl-pyridine (154.7 mg, 0.684 mmol), 1,4-dioxane (5 mL), copper iodide (12.96 mg, 0.0684 mmol), trans-1,2-diamino cyclohexane (23.39 mg, 0.2084 mmol) and potassium phosphate (434.6 mg, 2.05 mmol) to afford the crude product. Purification by preparative HPLC afforded 16 mg of the product (6.5% yield).

후처리

  1. customreaction conditions
  2. customto afford the crude product
  3. customPurification by preparative HPLC

출처 및 근거

ORD 기록
ord-90bd680009bf4821b311c019b71ece13
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946260B2

연결된 노트

불러오는 중…