Chlorotrimethylsilane → 2-(3-Chloro-4-fluorophenyl)ethan-1-amine

HRID 1843908노트

반응식

HRID 1843908 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]=[CH:9][N+:10]([O-])=O)[CH:5]=[CH:4][C:3]=1[F:13].[BH4-].[Li+].C[Si](Cl)(C)C>C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH2:10])[CH:5]=[CH:4][C:3]=1[F:13]

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 4148881Lithium borohydrideHCID 668018422-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene

생성물 1

HCID 224638772-(3-Chloro-4-fluorophenyl)ethan-1-amine수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Using the same reaction procedure and workup as described in Example 33, 2-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene (I-34a: 1.7 g, 8.4577 mmol) in dry THF (17 mL) was reacted with lithium borohydride (736.8 mg, 33.8308 mmol) and trimethylsilyl chloride (8.6 mL, 67.6616 mmol) in dry THF (9 mL) to afford 1.3 g of the product (100% yield).

후처리

  1. customthe same reaction procedure

출처 및 근거

ORD 기록
ord-217d9d13efc2488bb7b72be65b102e38
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946260B2

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