HCID 89963686, 화합물 → HCID 89964245, 화합물

HRID 1844026노트

반응식

HRID 1844026 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N+:12]([O-])=O)[C:8](=[O:15])[N:7]([C:16]1[CH:17]=[N:18][CH:19]=[CH:20][C:21]=1[CH3:22])[CH2:6][CH2:5]2>[Pd].CO>[NH2:12][C:11]1[CH:10]=[C:9]2[C:4]([CH2:5][CH2:6][N:7]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[CH3:22])[C:8]2=[O:15])=[CH:3][C:2]=1[CH3:1]

참가 물질

4

반응물 1

HCID 89963686HCID 89963686, 화합물

생성물 1

HCID 89964245HCID 89964245, 화합물수율 47.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

6-Methyl-2-(4-methylpyridin-3-yl)-7-nitro-3,4-dihydroisoquinolin-1(2H)-one (I-69f: 940 mg, 3.154 mmol) was reacted with 10% Pd—C (200 mg) and methanol (15 mL) to afford 400 mg of the product (36% yield). LCMS: 79.19%, m/z=268.1 (M+1)

출처 및 근거

ORD 기록
ord-accdc8ab09fc4367909e841624b886d6
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946260B2

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