2,6-Dichlorophenol → 3-(2-(Trifluoromethyl)phenoxy)propan-1-amine

HRID 1844404노트

반응식

HRID 1844404 반응식
Cl[C:2]1[CH:12]=[CH:11][CH:10]=[C:9](Cl)[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH2:8].[F:14][C:15]([F:24])([F:23])C1C=CC=CC=1O.ClC1C=CC=C(Cl)C=1O>>[F:14][C:15]([F:24])([F:23])[C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH2:8]

참가 물질

4

반응물 3

HCID 68992,6-DichlorophenolHCID 679582-TrifluoromethylphenolHCID 33042863-(2,6-Dichlorophenoxy)propan-1-amine

생성물 1

HCID 167833783-(2-(Trifluoromethyl)phenoxy)propan-1-amine수율 80%

실험 절차

Intermediate 10 (50 mg, 0.228 mmol, 80% yield) was prepared as a white powder following the procedure described for Intermediate 9 using 2-trifluoromethylphenol and 2.6-dichlorophenol as starting materials. LC-MS (ESI) 220 (M+H), RT=1.36 min (Method B).

출처 및 근거

ORD 기록
ord-858bfe3eab404260b6e44d87c5132574
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946430B2

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