HCID 10356009, 화합물 → 2-Hydroxy-4-(4-amino-phenoxy)-benzoic acid

HRID 18445노트

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HRID 18445 반응식
[OH:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>CCO.C1COCC1.[Pd]>[OH:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 1

HCID 10356009HCID 10356009, 화합물

생성물 1

HCID 104670322-Hydroxy-4-(4-amino-phenoxy)-benzoic acid수율 35%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A slurry of 2-hydroxy-4-(4-nitro-phenoxy)benzoic acid (950 mg; 3.5 mmol) in 99% EtOH (30 mL) and THF (0.5 mL) was added 5% Pd/C (100 mg) and stirred under H2 atmosphere (1 atm.) for 25 minutes. The black solution was filtered through celite and evaporated to dryness yielding 300 mg (35%) of a brown powder. Mp. 187-188° C.; MS (ESI+): 246 (MH+).

후처리

  1. filtrationThe black solution was filtered through celite
  2. customevaporated to dryness

출처 및 근거

ORD 기록
ord-d41b52a57aae469f902a4b7e6e561cc4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741352B2

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