N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine → 1-[2-(Dimethylamino)-2-methylpropyl]-1H-pyrazol-3-amine

HRID 1844539노트

반응식

HRID 1844539 반응식
[CH3:1][N:2]([CH3:15])[C:3]([CH3:14])([CH3:13])[CH2:4][N:5]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[N:6]1>[C].[Pd].C(O)C.C(OCC)(=O)C>[CH3:1][N:2]([CH3:15])[C:3]([CH3:13])([CH3:14])[CH2:4][N:5]1[CH:9]=[CH:8][C:7]([NH2:10])=[N:6]1

참가 물질

4

반응물 1

HCID 66880823N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine

생성물 1

HCID 583285031-[2-(Dimethylamino)-2-methylpropyl]-1H-pyrazol-3-amine수율 94%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 21584252Ethanol ethylacetate용매

실험 절차

N,N,2-trimethyl-1-(3-nitro-1H-pyrazol-1-yl)propan-2-amine (70.6 mg) was dissolved in a mixed solution (ethanol-ethyl acetate, 4:1, 5 mL). Then, 10% palladium-carbon (7 mg) was added to the prepared solution, and the solution was subjected to catalytic reduction at 101 kPa for about 2 hours. The reaction mixture was filtrated through Celite, and the filtrate was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (silica gel NH, ethyl acetate:hexane=1:1) to give the title compound as a yellow oil (56.8 mg, yield: 94%).

후처리

  1. filtrationThe reaction mixture was filtrated through Celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe obtained residue was purified by silica gel column chromatography (silica gel NH, ethyl acetate:hexane=1:1)

출처 및 근거

ORD 기록
ord-7017e47eadb446ed878822deea378193
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946440B2

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