Chlorosulfonic acid → Methyl 2-[5-bromo-2-(chlorosulfonyl)phenyl]acetate

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:14]([Cl:13])(=[O:16])=[O:15])=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:3]=1

참가 물질

반응물 2

HCID 24638Chlorosulfonic acid

HCID 11746402Methyl 2-(3-bromophenyl)acetate

생성물 1

HCID 90150774Methyl 2-[5-bromo-2-(chlorosulfonyl)phenyl]acetate

실험 절차

Methyl 2-(3-bromophenyl)acetate (22 g, 67 mmol) was slowly added into ClSO3H at −10° C. After 1 h, the mixture was warmed up to rt and stirred overnight, diluted slowly with ice water and extracted with EA. The organic layer was washed with water, dried over Na2SO4 and evaporated to give compound P15a (17 g, 54%).

후처리

extractionextracted with EA
washThe organic layer was washed with water
dry with materialdried over Na2SO4
customevaporated
customto give compound P15a (17 g, 54%)

출처 및 근거

ORD 기록: ord-6bdd0a8009b1423cbe5b959f58aecfca
출처 데이터셋: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08946446B2

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