Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 53417180, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzoic acid, 3,5-dibromo- | HCID 12063 | — |
| 반응물 | Ethane, azido- | HCID 79118 | — |
| 반응물 | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Thionyl Chloride | HCID 24386 | — |
| 생성물 | HCID 53417180 | HCID 53417180 | — |
반응 단계
The solution of 3,5-dibromobenzoic acid (26 g, 93 mmol) in SOCl2 (100 mL) was heated at reflux for 2 h, concentrated, diluted with dry DCM (300 mL) and added slowly to a stirred solution of N,O-dimethylhydroxylamine hydrochloride (9.75 g, 100 mmol) and EtN3 (28 g, 277 mmol) in dry DCM (300 mL) at 0° C. The solution was stirred for 1 h at rt, poured into water and the organic layer was separated. The organic layer was washed with water and brine, dried over Na2SO4, filtered and concentrated to give crude compound P37a (28 g, 93%) as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08946446B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-a71840bae54548e9944a5090f50bb903 |
| 출처 메모 | uspto-grants-2015_02 |