Chlorosulfonic acid → 5-(Cyclohexanecarbonyl)-1-methyl-1H-pyrrole-2-sulfonyl chloride

HRID 1844736노트

반응식

HRID 1844736 반응식
[CH:1]1([C:7]([C:9]2[N:10]([CH3:14])[CH:11]=[CH:12][CH:13]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:15][S:16](O)(=[O:18])=[O:17]>>[CH:1]1([C:7]([C:9]2[N:10]([CH3:14])[C:11]([S:16]([Cl:15])(=[O:18])=[O:17])=[CH:12][CH:13]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 14043405Cyclohexyl(1-methyl-1H-pyrrol-2-yl)methanone

생성물 1

HCID 823751515-(Cyclohexanecarbonyl)-1-methyl-1H-pyrrole-2-sulfonyl chloride수율 80%

반응 조건

온도
60 °C

실험 절차

To a solution of compound 25b (1.0 g, 5.2 mmol) was added portionwise chlorosulfonic acid (5 mL, 75 mmol) at 0° C., heated to 60° C. for 2 h, poured carefully into ice-water and extracted with CHCl3. The organic phase was dried (MgSO4), evaporated and purified by CC to give compound 25c (1.2 g, 80%).

후처리

  1. extractionextracted with CHCl3
  2. dry with materialThe organic phase was dried (MgSO4)
  3. customevaporated
  4. custompurified by CC

출처 및 근거

ORD 기록
ord-e63c9eadc5244481ae63e8b3dca8fb7a
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946446B2

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