참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-(tert-Butyl)-1-tosyl-1H-pyrrole-3-sulfonamide | HCID 86719139 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(tert-Butyl)-1H-pyrrole-3-sulfonamide | HCID 19693846 | 69% |
반응 단계
To a solution of compound 27c (665 mg, 1.87 mmol) in a mixture of THF (12 mL), MeOH (12 mL) and water (3 mL) was added K2CO3 (3.1 g, 22 mmol) and then the solution was heated at 60° C. overnight, cooled, acidified to pH=5 with AcOH and extracted with EA twice. The combined organic layers were washed with water (3×) and brine, concentrated and purified by CC (PE/EA=2/1) to give compound 27d (260 mg, 69%) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08946446B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_02 |
|---|
| ORD ID | ord-23659cd8d00544bf89aaaa18cadb6b73 |
|---|
| 출처 메모 | uspto-grants-2015_02 |
|---|
