Potassium Phosphate, Tribasic → 2-Methyl-8-(4-p-tolylpyridin-2-yl)benzofuro[2,3-b]pyridine

A mixture of 2-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine (2.5 g, 8.03 mmol), 2-chloro-4-(p-tolyl)pyridine (1.80 g, 8.83 mmol), Pd2(dba)3 (0.147 g 0.161 mmol), dicyclohexyl(2′,6′-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine (0.264 g, 0.642 mmol), potassium phosphate (5.96 g, 28.1 mmol), toluene (100 mL) and water (10 mL) was degassed with nitrogen and then refluxed overnight. The mixture was concentrated and extracted with ethyl acetate. The ethyl acetate layer was dried on Na2SO4 and then further purified by column chromatography using ethyl acetate in hexanes and washed with methanol to give 2-methyl-8-(4-(p-tolyl)pyridin-2-yl)benzofuro[2,3-b]pyridine (2.0 g, 5.71 mmol, 71% yield).

1. customwas degassed with nitrogen
2. temperaturerefluxed overnight
3. concentrationThe mixture was concentrated
4. extractionextracted with ethyl acetate
5. dry with materialThe ethyl acetate layer was dried on Na2SO4
6. customfurther purified by column chromatography
7. washwashed with methanol

ORD 기록

ord-f46434f9262744debd3cf905dc215234

출처 데이터셋

uspto-grants-2015_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08946697B1