Cyanogen Bromide → HCID 66940226, 화합물

HRID 1845059노트

반응식

HRID 1845059 반응식
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[C:7]([NH2:14])[C:6]=1[NH2:15])[CH3:2].COC(C1C2N=C(N)[NH:26][C:25]=2C=CC=1)=O.BrC#N>CO>[CH2:1]([O:3][C:4]([C:5]1[C:6]2[N:15]=[C:25]([NH2:26])[NH:14][C:7]=2[CH:8]=[C:9]([O:11][CH2:12][CH3:13])[CH:10]=1)=[O:16])[CH3:2]

참가 물질

5

반응물 3

HCID 10476Cyanogen BromideHCID 24730367methyl 2-amino-1H-benzo[d]imidazole-4-carboxylateHCID 669407232,3-Diamino-5-ethoxy-benzoic acid ethyl ester

생성물 1

HCID 66940226HCID 66940226, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

4.0 g (17.9 mmol) of 2,3-diamino-5-ethoxy-benzoic acid ethyl ester was subjected to a similar cyclization condition as illustrated in intermediate A by using 5.7 g (53.7 mmol) of BrCN in methanol to produce 2-amino-6-ethoxy-1H-benzoimidazole-4-carboxylic acid ethyl ester. LCMS: 250 (M+1)+.

출처 및 근거

ORD 기록
ord-d6809dce71be44fd9b7e6ff70c3ad49a
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946259B2

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