Potassium Hydroxide → 5-[(2R)-oxiran-2-yl]-2-(trifluoromethyl)pyridine

HRID 1845121노트

반응식

HRID 1845121 반응식
CC1C=CC(S(O[CH2:12][C@H:13]([OH:24])[C:14]2[CH:15]=[N:16][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:18][CH:19]=2)(=O)=O)=CC=1.[OH-].[K+]>C1COCC1>[O:24]1[CH2:12][C@H:13]1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:21])([F:22])[F:23])=[N:16][CH:15]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 86652106(R)-2-Hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-methylbenzenesulfonate

생성물 1

HCID 581880495-[(2R)-oxiran-2-yl]-2-(trifluoromethyl)pyridine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of (R)-2-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-methylbenzenesulfonate (1.0 g, 2.77 mmol) in THF (50 mL) was added powder potassium hydroxide (464 mg, 8.28 mmol) in small portions. The mixture was stirred for 40 minutes and TLC indicated completion of the reaction. The mixture was filtered through Celite and the filter cake was washed with acetonitrile (50 mL). The filtrate was carefully concentrated to a half volume and the obtained expoxide solution was used directly for the next step reaction.

후처리

  1. customcompletion of the reaction
  2. filtrationThe mixture was filtered through Celite
  3. washthe filter cake was washed with acetonitrile (50 mL)
  4. concentrationThe filtrate was carefully concentrated to a half volume
  5. customthe obtained expoxide solution was used directly for the next step reaction

출처 및 근거

ORD 기록
ord-9210e30ce6964e62af517c62aba28e50
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

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