Chloride → Methyl 4-chloro-3-(chlorosulfonyl)benzoate

HRID 1845147노트

반응식

HRID 1845147 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[S:11]([Cl:14])(=[O:13])=[O:12].[Cl-].[CH3:16]O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[CH:4][C:3]=1[S:11]([Cl:14])(=[O:12])=[O:13]

참가 물질

4

반응물 3

HCID 312ChlorideHCID 887MethanolHCID 756134-Chloro-3-(chlorosulphonyl)benzoic acid

생성물 1

HCID 18071846Methyl 4-chloro-3-(chlorosulfonyl)benzoate

실험 절차

A round bottom flask was charged with 4-chloro-3-(chlorosulfonyl)benzoic acid (16.0 g, 63.24 mmol) and methanol (100 mL), and thinoyl chloride (9.3 mL, 126.5 mmol) was added slowly at 0° C. The reaction mixture was then heated to reflux for 1.5 hours. The volatiles were removed under reduced pressure, and the residue was diluted with water and extracted with EtOAc. The solvents were removed under reduced pressure to get the title compound as a solid.

후처리

  1. additionwas added slowly at 0° C
  2. temperatureThe reaction mixture was then heated
  3. temperatureto reflux for 1.5 hours
  4. customThe volatiles were removed under reduced pressure
  5. additionthe residue was diluted with water
  6. extractionextracted with EtOAc
  7. customThe solvents were removed under reduced pressure

출처 및 근거

ORD 기록
ord-6f0667ae0f104694bb887cc47f59ed7c
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

반응 노트

불러오는 중…