Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1845192생성일: 2026년 10월 24일
Diisopropylethylamine → 4'-Methyl-5-(pyrrolidine-1-carbonyl)-N-(quinolin-7-ylmethyl)biphenyl-3-carboxamide
https://huagongshe.com/ko/reaction/1845192
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 반응물 | Quinolin-7-ylmethanamine | HCID 17904490 | — |
| 반응물 | 4'-Methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxylic acid | HCID 58187975 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4'-Methyl-5-(pyrrolidine-1-carbonyl)-N-(quinolin-7-ylmethyl)biphenyl-3-carboxamide | HCID 58187960 | — |
반응 단계
To a solution of 4′-methyl-5-(pyrrolidine-1-carbonyl)biphenyl-3-carboxylic acid (17 mg, 0.055 mmol) in N,N-dimethylformamide (0.5 mL) were added quinolin-7-ylmethanamine (34 mg, 0.22 mmol) (WO 2008/130481), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (80 mg, 0.21 mmol) and N,N-diisopropylethylamine (80 μL, 0.46 mmol). The reaction mixture was stirred at 50° C. for 16 hours. LC-MS indicated the reaction was complete. The reaction mixture was purified by preparative HPLC to afford the titile compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08946439B2 |
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| 출처 데이터셋 | uspto-grants-2015_02 |
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| ORD ID | ord-72a7f77af4c14f0c8ac195600c1d6d12 |
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| 출처 메모 | uspto-grants-2015_02 |
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