Chlorosulfonic acid → 5-(Chlorosulfonyl)-3-iodo-2-methylbenzoic acid
반응식
[Cl:1][S:2]([OH:5])(=O)=[O:3].[I:6][C:7]1[C:8]([CH3:16])=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11]>>[Cl:1][S:2]([C:14]1[CH:15]=[C:7]([I:6])[C:8]([CH3:16])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:5])=[O:3]참가 물질
3
반응 조건
- 온도
- 95 °C
실험 절차
A round bottom flask was charged with chlorosulfonic acid (3.80 mL, 57.2 mmol), and 3-iodo-2-methylbenzoic acid (5.00 g, 19.1 mmol) was added in portions at 0° C. The reaction was heated at 95° C. for two hours and then stirred at room temperature overnight. The reaction mixture was poured onto ice and the solids formed were collected and dried to afford the desired product as a white solid.
후처리
- additionwas added in portions at 0° C
- additionThe reaction mixture was poured onto ice
- customthe solids formed
- customwere collected
- customdried
출처 및 근거
- ORD 기록
- ord-7e4ff6ddcfeb45ef81acbef820676750
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946439B2
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