Diisopropylethylamine → N3,4'-Dimethyl-N5-((6-methylpyridin-3-yl)methyl)-N3-(pyridin-4-yl)biphenyl-3,5-dicarboxamide

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	4-(Methylamino)pyridine	HCID 123098	—
반응물	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
반응물	4'-Methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)biphenyl-3-carboxylic acid	HCID 58188051	—
용매	Dimethylformamide	HCID 6228	—
생성물	N3,4'-Dimethyl-N5-((6-methylpyridin-3-yl)methyl)-N3-(pyridin-4-yl)biphenyl-3,5-dicarboxamide	HCID 58188202	—

반응 조건

온도	25 °C

반응 단계

To a solution of 4′-methyl-5-((6-methylpyridin-3-yl)methylcarbamoyl)-biphenyl-3-carboxylic acid (50 mg, 0.134 mmol) in N,N-dimethylformamide (1 mL) were added N-methylpyridin-4-amine (40 mg, 0.37 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (120 mg, 0.32 mmol) and N,N-diisopropylethylamine (120 μL, 0.69 mmol). The reaction mixture was stirred for 16 hours at 25° C. The reaction mixture was purified by preparative HPLC to afford the final product as a light color solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08946439B2
출처 데이터셋	uspto-grants-2015_02
ORD ID	ord-648ab5c304614b94af63e29779fb5a6f
출처 메모	uspto-grants-2015_02