Ethyl 5-(hydroxymethyl)-4'-methylbiphenyl-3-carboxylate → Ethyl 5-formyl-4'-methylbiphenyl-3-carboxylate

HRID 1845257노트

반응식

HRID 1845257 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[CH:8]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH:2]([C:3]1[CH:4]=[C:5]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:6]=[C:7]([C:9]2[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=2)[CH:8]=1)=[O:1]

참가 물질

4

반응물 1

HCID 58188190Ethyl 5-(hydroxymethyl)-4'-methylbiphenyl-3-carboxylate

생성물 1

HCID 58188063Ethyl 5-formyl-4'-methylbiphenyl-3-carboxylate

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of ethyl 5-(hydroxymethyl)-4′-methylbiphenyl-3-carboxylate (400 mg, 1.5 mmol) and manganese(IV) oxide (660 mg, 6.6 mmol) in methylene chloride (14 mL) was stirred at room temperature overnight. The reaction mixture was filtered through Celite and washed with methylene chloride. The filtrate was concentrated to afford the title compound.

후처리

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with methylene chloride
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-e35decb50e3d4e4d9d5307a8910fa373
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

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