Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dibutyltin oxide → 2-Hydroxy-4-octyloxy-benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dibutyltin oxide | HCID 61221 | — |
| 반응물 | 2-Hydroxy-4-octyloxy-benzamide | HCID 10445570 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Hydroxy-4-octyloxy-benzonitrile | HCID 10106026 | 14.4% |
반응 단계
A solution of 2-hydroxy-4-octyloxy-benzamide (5.21 g; 19.7 mmol) and dibutyltinoxide (3.65 g; 14.6 mmol) was refluxed in toluene (60 mL) for 12 days. The reaction mixture was evaporated to dryness on SiO2 and purified by column chromatography (SiO2; EtOAc/PE80-100° C.=1:4) to yield 700 mg (14%) product as yellow crystals. Mp. 69-71° C. MS (Direct; Cl): 248 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741352B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-6c54fae39cb14701a9a8fe9b4c28e164 |
| 출처 메모 | uspto-grants-2010_06 |