Methyl 4,5-Dibromo-2-furancarboxylate → Methyl 4-bromo-5-methylfuran-2-carboxylate

HRID 1845697

반응식

HRID 1845697 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([O:10][CH3:11])=[O:9])[O:5][C:6]=1Br.Cl[Zn][CH3:14]>C1COCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([O:10][CH3:11])=[O:9])[O:5][C:6]=1[CH3:14]

참가 물질

5

반응물 2

HCID 4135083Methyl 4,5-Dibromo-2-furancarboxylateHCID 178477798HCID 178477798, 화합물

생성물 1

HCID 604544Methyl 4-bromo-5-methylfuran-2-carboxylate수율 72%

시약·촉매·용매 2

HCID 178418476HCID 178418476, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 4,5-dibromo-2-furancarboxylate (4.5 g, 15.85 mmol) and BIS(TRIPHENYLPHOSPHINE)PALLADIUM(II) CHLORIDE (0.38 g, 0.541 mmol) in THF (100 mL) at RT was added chloro(methyl)zinc (15 mL, 30 mmol) dropwise. After stirring for 10 h, the reaction was quenched with NH4Cl (sat'd) (50 mL). The mixture was extracted with EtOAc (50 mL×3), and the collected organic layers were dried over MgSO4. Solvent was removed under vacuum and the resulting residue was purified via column chromatography (silica, EtOAc/Hex 10-20%) to give the title compound (2.5 g, 72%) as a white solid: LC-MS (ES) m/z 220 (M+H)+.

후처리

  1. customthe reaction was quenched with NH4Cl (sat'd) (50 mL)
  2. extractionThe mixture was extracted with EtOAc (50 mL×3)
  3. dry with materialthe collected organic layers were dried over MgSO4
  4. customSolvent was removed under vacuum
  5. customthe resulting residue was purified via column chromatography (silica, EtOAc/Hex 10-20%)

출처 및 근거

ORD 기록
ord-0cf7215562f1448a868bae8bfbfd8b32
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946278B2

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