Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Hydroxy-4-nitrobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Methoxy-4-nitrobenzonitrile | HCID 291867 | — |
| 반응물 | Pyridinium chloride | HCID 10176127 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-Hydroxy-4-nitrobenzonitrile | HCID 286148 | 95.2% |
반응 단계
Pyridine hydrochloride (100 g; 0.87 mol) and 2-methoxy-4-nitro-benzonitrile (17 g; ca 96 mmol) was heated to 200° C. for 2 hours, cooled to room temperature and carefully added H2O and EtOAc. The slurry was stirred until all solid dissolved. The organic layer was isolated, washed twice with H2O, brine then dried, filtered and evaporated to dryness to yield 15 g (95%) pure product
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741352B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-572a2f4a537f4d7ba786d836abdcf52a |
| 출처 메모 | uspto-grants-2010_06 |