Water → 2-Hydroxy-4-nitrobenzonitrile

HRID 18458

반응식

HRID 18458 반응식
Cl.N1C=CC=CC=1.C[O:9][C:10]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:11]=1[C:12]#[N:13].O>CCOC(C)=O>[OH:9][C:10]1[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[CH:15]=[CH:14][C:11]=1[C:12]#[N:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 2918672-Methoxy-4-nitrobenzonitrileHCID 10176127Pyridinium chloride

생성물 1

HCID 2861482-Hydroxy-4-nitrobenzonitrile수율 95.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Pyridine hydrochloride (100 g; 0.87 mol) and 2-methoxy-4-nitro-benzonitrile (17 g; ca 96 mmol) was heated to 200° C. for 2 hours, cooled to room temperature and carefully added H2O and EtOAc. The slurry was stirred until all solid dissolved. The organic layer was isolated, washed twice with H2O, brine then dried, filtered and evaporated to dryness to yield 15 g (95%) pure product

후처리

  1. dissolutiondissolved
  2. customThe organic layer was isolated
  3. washwashed twice with H2O, brine
  4. customthen dried
  5. filtrationfiltered
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-572a2f4a537f4d7ba786d836abdcf52a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741352B2

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