(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine → (S)-3-(1-(2,6-Dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine

HRID 1845894노트

반응식

HRID 1845894 반응식
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[C@@H:10]([O:12][C:13]1[C:14]([N+:19]([O-])=O)=[N:15][CH:16]=[CH:17][CH:18]=1)[CH3:11]>C(O)C.[Pd]>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[C@@H:10]([O:12][C:13]1[C:14]([NH2:19])=[N:15][CH:16]=[CH:17][CH:18]=1)[CH3:11]

참가 물질

4

반응물 1

HCID 86327669(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

생성물 1

HCID 86327671(S)-3-(1-(2,6-Dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine수율 87%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The compound (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (15.2 g, 45.9 mmol) was suspended in ethanol (150 mL), and palladium/carbon was added to perform the hydrogenation reaction. TLC test showed that the raw materials were completely reacted. The reaction liquid was filtered; the filtrate was concentrated under reduced pressure to remove ethanol to yield (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-aminopyridine (12 g, yield: 87%).

후처리

  1. customthe hydrogenation reaction
  2. customwere completely reacted
  3. customThe reaction liquid
  4. filtrationwas filtered
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customto remove ethanol

출처 및 근거

ORD 기록
ord-5fe28263153a4bbc992eb0b5e618e4d9
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952002B2

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