Cyclopentylamine → 5-Chloro-N3-cyclopentylpyridazine-3,4-diamine

HRID 1846005노트

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HRID 1846005 반응식
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]([Cl:9])[C:7]=1[NH2:8].[CH:10]1([NH2:15])[CH2:14][CH2:13][CH2:12][CH2:11]1>O>[Cl:9][C:6]1[C:7]([NH2:8])=[C:2]([NH:15][CH:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)[N:3]=[N:4][CH:5]=1

참가 물질

4

반응물 2

HCID 2906CyclopentylamineHCID 64032013,5-Dichloro-1,4-dihydropyridazin-4-imine

생성물 1

HCID 867232335-Chloro-N3-cyclopentylpyridazine-3,4-diamine수율 90%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
150 °C

실험 절차

3,5-Dichloropyridazin-4-amine (Preparation 4, 1 g, 6.09 mmol) was added to cyclopentylamine (3.0 mL, 30.41 mmol) and water (1 mL) in a stainless steel sealed container. The mixture was heated for 16 hours at 150° C. The reaction mixture was cooled to room temperature then evaporated in vacuo. The residue was purified by silica gel column chromatography eluting with EtOAc to afford the title compound as yellow solid in 90% yield, 1.17 g.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customthen evaporated in vacuo
  3. customThe residue was purified by silica gel column chromatography
  4. washeluting with EtOAc

출처 및 근거

ORD 기록
ord-1f4dc9d1574540559185f6c4003763ef
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952008B2

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