2,2-Difluoroethan-1-ol → 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid

HRID 1846089노트

반응식

HRID 1846089 반응식
Cl[C:2]1[N:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:14][CH:15]([F:18])[CH2:16][OH:17].CC([O-])(C)C.[K+].C(Cl)Cl.CCO>C1COCC1>[F:14][CH:15]([F:18])[CH2:16][O:17][C:2]1[N:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

6

반응물 4

HCID 1361872,2-Difluoroethan-1-olHCID 125426642-Chloro-5-nitronicotinic acidHCID 21584144Dichloromethane ethanolHCID 23665647Potassium tert-butoxide

생성물 1

HCID 866586692-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Prepared analogously to Example 5a from 2 chloro-5-nitro nicotinic acid and 2,2-difluoroethanol with KOtBu in THF. Yield: (25%). MS [M−H]−=247; TLC: Rf=0.13 (silica gel, DCM:EtOH 9:1).

출처 및 근거

ORD 기록
ord-452cab8c4fac48359adc1ae88ceaf743
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08951999B2

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