Hydroxylamine → Ethyl 6-chloro-2-fluoro-3-((hydroxyimino)methyl)benzoate

HRID 1846107노트

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HRID 1846107 반응식
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH:12]=O)[C:6]=1[F:14])[CH3:2].[NH2:16][OH:17]>CO>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH:12]=[N:16][OH:17])[C:6]=1[F:14])[CH3:2]

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 58483266Ethyl 6-chloro-2-fluoro-3-formylbenzoate

생성물 1

HCID 76800184Ethyl 6-chloro-2-fluoro-3-((hydroxyimino)methyl)benzoate

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
55 °C

실험 절차

A mixture of 6-chloro-2-fluoro-3-formyl-benzoic acid ethyl ester (4.04 g; 17.52 mmol), hydroxylamine (50% aq. solution, 4.29 mL; 70 mmol) in MeOH (60 mL) was stirred at 55° C. for 1.5 h. The mixture was concentrated i. vac., diluted with EtOAc, washed with brine, dried over Na2SO4 and concentrated i.vac. to furnish the subtitle compound.

후처리

  1. concentrationThe mixture was concentrated i
  2. addition, diluted with EtOAc
  3. washwashed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated i.vac

출처 및 근거

ORD 기록
ord-dd0871d3f04b4e3790673be115def190
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08951999B2

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