Sodium Methoxide → 2-Bromo-6-methoxypyridin-3-ol

HRID 1846236노트

반응식

HRID 1846236 반응식
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[CH3:10][O-:11].[Na+]>CN(C=O)C>[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([O:11][CH3:10])[N:3]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 467386822-Bromo-6-chloropyridin-3-ol

생성물 1

HCID 899642662-Bromo-6-methoxypyridin-3-ol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a 0° C. solution of 2-bromo-6-chloropyridin-3-ol (1 eq.) and DMF (0.2 M) is added NaOMe (2.2 eq.). The solution is allowed to warm to room temperature as the cooling bath expires and allowed to stir at room temperature for 24 h. The reaction is quenched with saturated NH4Cl and diluted with water. The aqueous solution is extracted with EtOAc. The combined EtOAc layers are dried over MgSO4, concentrated in vacuo, and purified by column chromatography to give the title compound.

후처리

  1. customThe reaction is quenched with saturated NH4Cl
  2. additiondiluted with water
  3. extractionThe aqueous solution is extracted with EtOAc
  4. dry with materialThe combined EtOAc layers are dried over MgSO4
  5. concentrationconcentrated in vacuo
  6. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-da3795bddaca487fa6f4a27f388fbeab
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952009B2

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