3,4-Dinitrobenzaldehyde → 3-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one

HRID 1846365노트

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HRID 1846365 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[N+:12]([O-:14])=[O:13])[CH:7]=O)([O-:3])=[O:2].[NH2:15][C:16]1[CH:34]=[CH:33][CH:32]=[CH:31][C:17]=1[C:18]([NH:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH2:29][CH3:30])[CH3:28])=[CH:23][CH:22]=1)=[O:19]>CCO>[CH:27]([C:24]1[CH:25]=[CH:26][C:21]([N:20]2[C:18](=[O:19])[C:17]3[C:16](=[CH:34][CH:33]=[CH:32][CH:31]=3)[N:15]=[C:7]2[C:6]2[CH:9]=[CH:10][C:11]([N+:12]([O-:14])=[O:13])=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)=[CH:22][CH:23]=1)([CH2:29][CH3:30])[CH3:28]

참가 물질

4

반응물 2

HCID 33622013,4-DinitrobenzaldehydeHCID 167700372-Amino-N-(4-sec-butylphenyl)benzamide

생성물 1

HCID 866598193-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one수율 49%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Anhydrous CuCl2 (0.370 g, 2.70 mmol) and 3,4-dinitrobenzaldehyde (0.270 g, 1.38 mmol) were added to a solution of 2-amino-N-(4-sec-butylphenyl)benzamide (0.370 g, 1.38 mmol) in anhydrous EtOH (20 mL). After heating to reflux temperature for 3 hours, the mixture was concentrated in vacuo. The residue was dissolved in EtOAc, washed with H2O, then brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification by flash chromatography on silica gel, eluting with 10% to 60% EtOAc in heptane, afforded 3-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one (0.300 g, 49%).

후처리

  1. temperatureAfter heating
  2. temperatureto reflux temperature for 3 hours
  3. concentrationthe mixture was concentrated in vacuo
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with H2O
  6. dry with materialbrine, dried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customPurification by flash chromatography on silica gel
  10. washeluting with 10% to 60% EtOAc in heptane

출처 및 근거

ORD 기록
ord-acc75f227e3946808c31f9dbff642dbc
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952021B2

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