3-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one → 3-(4-sec-butylphenyl)-2-(3,4-diaminophenyl)quinazolin-4(3H)-one

HRID 1846366노트

반응식

HRID 1846366 반응식
[CH:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]2[C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-])=O)=[C:24]([N+:31]([O-])=O)[CH:23]=2)=[CH:7][CH:6]=1)([CH2:3][CH3:4])[CH3:2]>CCO>[CH:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]2[C:22]2[CH:27]=[CH:26][C:25]([NH2:28])=[C:24]([NH2:31])[CH:23]=2)=[CH:9][CH:10]=1)([CH2:3][CH3:4])[CH3:2]

참가 물질

3

반응물 1

HCID 866598193-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one

생성물 1

HCID 866598203-(4-sec-butylphenyl)-2-(3,4-diaminophenyl)quinazolin-4(3H)-one수율 62.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3-(4-sec-butylphenyl)-2-(3,4-dinitrophenyl)quinazolin-4(3H)-one (0.240 g, 0.54 mmol) was dissolved in EtOH (20 mL) and flushed with N2 for 15 minutes. Pd/C (0.025 g, 10 wt %) was added, and stirred under 1 atmosphere of H2 overnight. After flushing with N2, the mixture was filtered through diatomaceous earth. The filtrate was concentrated and purified by flash chromatography on silica gel, eluting with 0% to 10% MeOH in EtOAc, to afford 3-(4-sec-butylphenyl)-2-(3,4-diaminophenyl)quinazolin-4(3H)-one (0.130 g, 62%).

후처리

  1. customflushed with N2 for 15 minutes
  2. additionPd/C (0.025 g, 10 wt %) was added
  3. customAfter flushing with N2
  4. filtrationthe mixture was filtered through diatomaceous earth
  5. concentrationThe filtrate was concentrated
  6. custompurified by flash chromatography on silica gel
  7. washeluting with 0% to 10% MeOH in EtOAc

출처 및 근거

ORD 기록
ord-77c01d0d43424793bc47aecf07e091a2
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952021B2

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