Water → 6-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

HRID 1846418노트

반응식

HRID 1846418 반응식
[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:25]=[C:24](Cl)[N:23]=[CH:22][N:21]=1.O>CN(C=O)C>[Cl:19][C:20]1[N:21]=[CH:22][N:23]=[C:24]([O:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:25]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669780936-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one

생성물 1

HCID 866638916-(6-chloro-pyrimidin-4-yloxy)-4-methyl-3H-benzoxazol-2-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.10 g (0.60 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one in 1.5 mL DMF were combined with 0.10 g (0.70 mmol) potassium carbonate and stirred for 15 min at RT. Then 0.10 g (0.60 mmol) 4,6-dichloropyrimidine were added to the reaction mixture and stirred overnight at RT. Then water was added and the precipitate formed was suction filtered, washed and dried i. vac.

후처리

  1. stirringstirred overnight at RT
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed
  5. customdried i

출처 및 근거

ORD 기록
ord-07131b398064435881a0d3a6fe1e5e0c
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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