Trifluoroacetic acid → 6-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

HRID 1846427노트

반응식

HRID 1846427 반응식
C(O)(C(F)(F)F)=O.[CH3:8][C:9]1[C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=[C:11]([NH:19]C(=O)OC(C)(C)C)[CH:10]=1>C(Cl)Cl>[NH2:19][C:11]1[CH:10]=[C:9]([CH3:8])[C:14]2[NH:15][C:16](=[O:18])[O:17][C:13]=2[CH:12]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67126852Tert-butyl (4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate

생성물 1

HCID 199116046-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

400 μL (5.30 mmol) TFA were added to 230 mg (0.900 mmol) tert-butyl (4-methyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-carbamate in 5.0 ml DCM and the mixture was stirred for 1.5 h at RT. The reaction mixture was evaporated down and the residue was divided between semisaturated sodium hydrogen carbonate solution and EtOAc. The organic phase was dried on sodium sulphate, filtered and evaporated down.

후처리

  1. customThe reaction mixture was evaporated down
  2. customThe organic phase was dried on sodium sulphate
  3. filtrationfiltered
  4. customevaporated down

출처 및 근거

ORD 기록
ord-baf8ec1fae1d465cbd77798864253e97
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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