Water → HCID 86663906, 화합물

HRID 1846448노트

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HRID 1846448 반응식
C(=O)([O-])[O-].[K+].[K+].Cl[C:8]1[CH:13]=[C:12]([Cl:14])[N:11]=[C:10]([CH3:15])[N:9]=1.[OH:16][C:17]1[CH:26]=[C:25]([CH3:27])[C:20]2[NH:21][C:22](=[O:24])[O:23][C:19]=2[CH:18]=1.O>CN(C=O)C>[Cl:14][C:12]1[N:11]=[C:10]([CH3:15])[N:9]=[C:8]([O:16][C:17]2[CH:26]=[C:25]([CH3:27])[C:20]3[NH:21][C:22](=[O:24])[O:23][C:19]=3[CH:18]=2)[CH:13]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 2349974,6-Dichloro-2-methylpyrimidineHCID 669780936-hydroxy-4-methylbenzo[d]oxazol-2(3H)-one

생성물 1

HCID 86663906HCID 86663906, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

100 mg (0.724 mmol) potassium carbonate and 110 mg (0.655 mmol) 4,6-dichloro-2-methyl-pyrimidine were added to 100 mg (0.575 mmol) 6-hydroxy-4-methyl-3H-benzoxazol-2-one in 1.5 mL DMF and the mixture was stirred for 2 h at RT. Then 15 mL water were added and the mixture was stirred overnight at RT. The precipitate formed was suction filtered, washed with water and dried i. vac.

후처리

  1. stirringthe mixture was stirred overnight at RT
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. customdried i

출처 및 근거

ORD 기록
ord-f9a7d0a08fda4b09b0e8818a014a419b
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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