Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Tetrahydrofuran-3-carbonyl chloride | HCID 14020412 | — |
| 반응물 | 4-Amino-3-chloro-5-nitrophenol | HCID 66978338 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(2-chloro-4-hydroxy-6-nitrophenyl)tetrahydrofuran-3-carboxamide | HCID 66978219 | — |
반응 단계
0.40 g (2.12 mmol) 4-amino-3-chloro-5-nitrophenol were placed in 5 mL DCM. 0.44 mL DIPEA and 0.34 g tetrahydrofuran-3-carbonyl chloride were added and the mixture was stirred for 2 h at RT. A further 0.34 g tetrahydrofuran-3-carbonyl chloride was added and the mixture was stirred overnight at RT. The reaction mixture was diluted with DCM and washed with water. The organic phase was evaporated down i.vac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08952014B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-750612a2b2be49fea853381032bdd2ab |
| 출처 메모 | uspto-grants-2015_02 |