p-Toluenesulfonic acid monohydrate → HCID 178516181, 화합물
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]([CH:13]1[CH2:17][CH2:16][O:15][CH2:14]1)=O.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:9][C:4]1[C:3]2[NH:10][C:11]([CH:13]3[CH2:17][CH2:16][O:15][CH2:14]3)=[N:1][C:2]=2[CH:7]=[C:6]([OH:8])[CH:5]=1참가 물질
4
실험 절차
0.10 g (0.39 mmol) N-(2-amino-6-chloro-4-hydroxyphenyl)tetrahydrofuran-3-carboxamide were placed in 20 mL methanol, a spatula tip of p-toluenesulphonic acid monohydrate was added and the mixture was boiled for 2 h. The reaction mixture was evaporated down i.vac. and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.
후처리
- customThe reaction mixture was evaporated down i.vac
- customand purified by chromatography
- additionThe fractions containing product
- customevaporated down i.vac
출처 및 근거
- ORD 기록
- ord-d47bc832bb53472b83595fbb6a198255
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08952014B2
반응 노트
불러오는 중…