Pyridinium chloride → 2-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

HRID 1846515노트

반응식

HRID 1846515 반응식
C[O:2][C:3]1[CH:4]=[C:5]([C:13]([F:16])([F:15])[F:14])[C:6]2[N:10]=[C:9]([CH3:11])[NH:8][C:7]=2[CH:12]=1.Cl.N1C=CC=CC=1>CN(C=O)C>[CH3:11][C:9]1[NH:8][C:7]2[CH:12]=[C:3]([OH:2])[CH:4]=[C:5]([C:13]([F:16])([F:14])[F:15])[C:6]=2[N:10]=1

참가 물질

4

반응물 2

HCID 10176127Pyridinium chlorideHCID 669782136-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole

생성물 1

HCID 669782592-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A well stirred mixture of 450 mg (1.95 mmol) 6-methoxy-2-methyl-4-trifluoromethyl-1H-benzimidazole and 2.50 g (21.6 mmol) pyridine hydrochloride was heated for 15 min to 200° C. After cooling to RT the reaction mixture was combined with 3.0 mL DMF and purified by preparative HPLC. The fractions containing product were combined and evaporated down i.vac.

후처리

  1. temperaturewas heated for 15 min to 200° C
  2. custompurified by preparative HPLC
  3. additionThe fractions containing product
  4. customevaporated down i.vac

출처 및 근거

ORD 기록
ord-68c0fe24adfa46c5894f204c1205570c
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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