Potassium Carbonate → 6-(6-chloro-pyrimidin-4-yloxy)-2-methyl-4-trifluoromethyl-1H-benzimidazole

HRID 1846516노트

반응식

HRID 1846516 반응식
C(=O)([O-])[O-].[K+].[K+].Cl[C:8]1[CH:13]=[C:12]([Cl:14])[N:11]=[CH:10][N:9]=1.[CH3:15][C:16]1[NH:17][C:18]2[CH:24]=[C:23]([OH:25])[CH:22]=[C:21]([C:26]([F:29])([F:28])[F:27])[C:19]=2[N:20]=1>CN(C=O)C>[Cl:14][C:12]1[N:11]=[CH:10][N:9]=[C:8]([O:25][C:23]2[CH:22]=[C:21]([C:26]([F:29])([F:28])[F:27])[C:19]3[N:20]=[C:16]([CH3:15])[NH:17][C:18]=3[CH:24]=2)[CH:13]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669782592-methyl-7-trifluoromethyl-3H-benzimidazol-5-ol

생성물 1

HCID 866639306-(6-chloro-pyrimidin-4-yloxy)-2-methyl-4-trifluoromethyl-1H-benzimidazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

221 mg (1.60 mmol) potassium carbonate were added at RT to 245 mg (1.60 mmol) 4,6-dichloropyrimidine and 330 mg (1.52 mmol) 2-methyl-7-trifluoromethyl-3H-benzimidazole-5-ol in 5.0 mL DMF and the mixture was stirred overnight at RT. The reaction mixture was poured onto water. The precipitate formed was filtered off, washed with water and dried.

후처리

  1. additionThe reaction mixture was poured onto water
  2. customThe precipitate formed
  3. filtrationwas filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-5c5c21a408ae447dad8cdcab8db44074
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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