3-Benzyloxycyclobutane-1,1-dicarboxylic acid → 3-(Benzyloxy)cyclobutane-1-carboxylic acid

HRID 1846753노트

반응식

HRID 1846753 반응식
[CH2:1]([O:8][CH:9]1[CH2:12][C:11](C(O)=O)([C:13]([OH:15])=[O:14])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>N1C=CC=CC=1>[CH2:1]([O:8][CH:9]1[CH2:10][CH:11]([C:13]([OH:15])=[O:14])[CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 6387653-Benzyloxycyclobutane-1,1-dicarboxylic acid

생성물 1

HCID 128151113-(Benzyloxy)cyclobutane-1-carboxylic acid수율 95%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (1.5 g, 5.99 mmol) in pyridine (3 mL) was heated in a 120° C. oil bath for 12 h. The mixture was cooled to RT and the pyridine was removed under vacuum. Toluene (10 mL) was added and the solution was washed with 1N HCl (3×), dried (MgSO4), filtered, and concentrated in vacuo to give product as a brown oil (1.17 g, 95%).

후처리

  1. customthe pyridine was removed under vacuum
  2. additionToluene (10 mL) was added
  3. washthe solution was washed with 1N HCl (3×)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-161fb393cbd24dc28f77b7822cf23a18
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952037B2

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