HCID 178522112, 화합물 → HCID 178522109, 화합물

HRID 1846802노트

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HRID 1846802 반응식
C([O:8][C@H:9]1[CH2:12][C@H:11]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[O:14])[CH2:10]1)C1C=CC=CC=1>C(O)C.[OH-].[Pd+2].[OH-]>[OH:8][C@H:9]1[CH2:12][C@H:11]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[O:14])[CH2:10]1

참가 물질

4

반응물 1

HCID 178522112HCID 178522112, 화합물

생성물 1

HCID 178522109HCID 178522109, 화합물

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

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온도
70 °C

실험 절차

trans-3-(benzyloxy)-N-(pyridin-2-yl)cyclobutanecarboxamide (0.394 g, 1.40 mmol) and palladium hydroxide (0.098 g, 0.14 mmol, 20 weight % on carbon) were mixed in ethanol (5 mL). The reaction mixture was placed under a hydrogen atmosphere (balloon) and stirred at 70° C. for 20 h. The reaction mixture was cooled to RT and filtered. The filtrate was concentrated, and the resulting crude product was purified via silica gel chromatography to give trans-3-hydroxy-N-(pyridin-2-yl)cyclobutanecarboxamide as an off white solid.

후처리

  1. temperatureThe reaction mixture was cooled to RT
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated
  4. customthe resulting crude product was purified via silica gel chromatography

출처 및 근거

ORD 기록
ord-fad087c2c0884ee58f95d65885fa6bd6
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952037B2

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